Coronaviruses are a group of viruses that usually cause mild illnesses, such as the common cold. However, certain types of coronavirus can infect the lower airway, causing serious illnesses like pneumonia or bronchitis. Most people get infected with coronaviruses at some point in their lives and the majority of these infections are harmless. The new coronavirus that causes the covid-19 illness is a notable exception.
Coronaviruses have extraordinarily large single-stranded RNA genomes – approximately 26,000 to 32,000 bases or RNA “letters” in length. Coronavirus particles are surrounded by a fatty outer layer called an envelope and usually appear spherical, as seen under an electron microscope, with a crown or “corona” of club-shaped spikes on their surface.
Coronaviruses replicate their RNA genomes using enzymes called RNA-dependent RNA polymerases, which are prone to errors, but genomic analysis so far suggests that covid-19 is mutating slowly, reducing the chance of it changing to become more deadly.
There are currently no vaccines or specific drug treatments for coronaviruses, but efforts to develop a vaccine are underway and HIV and Ebola drugs are being tested in people with covid-19.
On 18 March, the World Health Organization (WHO) said they had begun a trial of the most promising drugs, including the long-used antimalarial drugs chloroquine and hydroxychloroquine, a new antiviral drug called remdesivir and a combination of two HIV drugs called lopinavir and ritonavir. The HIV drugs will also be tested in combination with an antiviral called interferon beta.
On 22 March, several countries in Europe, including the UK, launched a collaborative trial of the same drugs, which will complement the WHO effort.
Many other potential treatments are being explored, particularly the possibility of developing antibodies against covid-19.
Other severe coronaviruses
At least two other types of human coronavirus – Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) – are known to cause severe symptoms.
SARS-CoV first emerged in 2002 in Guangdong, China as an unusual pneumonia, which developed into life-threatening respiratory failure in certain cases. The virus rapidly spread across 29 countries, infecting more than 8000 people and killing about 800.
The MERS-CoV epidemic appeared in Saudi Arabia in 2012, with people experiencing similar symptoms to SARS-CoV but dying at a much higher rate of 34 per cent. Unlike SARS-CoV, which spread quickly and widely, MERS-CoV has been mainly limited to the Middle East.
Spread from animals to people
Coronaviruses are zoonotic, meaning that they can be transmitted to people from animals. Both SARS-CoV and MERS-CoV originally came from bats, though other animals – including camels in the case of MERS – can act as intermediaries that spread coronaviruses to humans.
Many of the early cases of covid-19 were traced back to a large seafood and animal market in Wuhan. The virus is thought to have come from bats, possibly via an intermediary animal.
How to Prevent
- There is currently no vaccine to prevent coronavirus disease 2019 (COVID-19).
- The best way to prevent illness is to avoid being exposed to this virus.
- The virus is thought to spread mainly from person-to-person.
- Between people who are in close contact with one another (within about 6 feet).
- Through respiratory droplets produced when an infected person coughs, sneezes or talks.
- These droplets can land in the mouths or noses of people who are nearby or possibly be inhaled into the lungs.
- Some recent studies have suggested that COVID-19 may be spread by people who are not showing symptoms.
Everyone Should:
Clean your hands often
- Wash your hands often with soap and water for at least 20 seconds especially after you have been in a public place, or after blowing your nose, coughing, or sneezing.
- If soap and water are not readily available, use a hand sanitizer that contains at least 60% alcohol. Cover all surfaces of your hands and rub them together until they feel dry.
- Avoid touching your eyes, nose, and mouth with unwashed hands.
Avoid close contact
- Avoid close contact with people who are sick
- Stay home as much as possible.pdf iconexternal icon
- Put distance between yourself and other people.
- Remember that some people without symptoms may be able to spread virus.
- Keeping distance from others is especially important for people who are at higher risk of getting very sick.
Take steps to protect others
Stay home if you’re sick
Stay home if you are sick, except to get medical care. Learn what to do if you are sick.
Cover coughs and sneezes
- Cover your mouth and nose with a tissue when you cough or sneeze or use the inside of your elbow.
- Throw used tissues in the trash.
- Immediately wash your hands with soap and water for at least 20 seconds. If soap and water are not readily available, clean your hands with a hand sanitizer that contains at least 60% alcohol.
Wear a facemask if you are sick
- If you are sick: You should wear a facemask when you are around other people (e.g., sharing a room or vehicle) and before you enter a healthcare provider’s office. If you are not able to wear a facemask (for example, because it causes trouble breathing), then you should do your best to cover your coughs and sneezes, and people who are caring for you should wear a facemask if they enter your room. Learn what to do if you are sick.
- If you are NOT sick: You do not need to wear a facemask unless you are caring for someone who is sick (and they are not able to wear a facemask). Facemasks may be in short supply and they should be saved for caregivers
Clean and disinfect
- Clean AND disinfect frequently touched surfaces daily. This includes tables, doorknobs, light switches, countertops, handles, desks, phones, keyboards, toilets, faucets, and sinks.
- If surfaces are dirty, clean them: Use detergent or soap and water prior to disinfection.
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MUHAMMAD ASAD ULLAH
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